THE STEPWISE DEGRADATION OF A GLYCOSYLATED ALDOSE - A POTENTIAL METHOD FOR SEQUENCING BRANCHED OLIGOSACCHARIDES

被引：3

作者：

JAGER, B ^{[1
]}

LAY, H ^{[1
]}

LEHMANN, J ^{[1
]}

ZISER, L ^{[1
]}

机构：

[1] UNIV FREIBURG,INST ORGAN CHEM & BIOCHEM,ALBERTSTR 21,W-7800 FREIBURG,GERMANY

来源：

CARBOHYDRATE RESEARCH | 1991年 / 217卷

关键词：

D O I：

10.1016/0008-6215(91)84120-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

2,3,6,2',3',4',6'-Hepta-O-methylmaltose diethyl dithioacetal (2), obtained under mild conditions from N-methyl-hepta-O-methyl-N-p-nitrophenyl-beta-maltosylamine (1), was converted into the disulfone 4. Storage of a solution of 4 in aqueous tetrahydrofuran gave 1,2-dideoxy-1,1-bis(ethylsulfonyl)hepta-O-methylmalt-1-enitol (5). Fragmentation of 5 with aqueous ammonia released 2,3,4,6-tetra-O-methyl-D-glucose. This degradation procedure has potential for the sequencing of branched oligosaccharides.

引用

页码：99 / 106

页数：8

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