THE EFFECT OF HIGH-DOSE STEROIDS ON MRI GADOLINIUM ENHANCEMENT IN ACUTE DEMYELINATING LESIONS

被引：83

作者：

BURNHAM, JA

WRIGHT, RR

DREISBACH, J

MURRAY, RS

机构：

[1] ROCKY MT MULTIPLE SCLEROSIS CTR,ENGLEWOOD,CO

[2] COLORADO NEUROL INST,ENGLEWOOD,CO

[3] SWEDISH MED CTR,ENGLEWOOD,CO

[4] UNIV COLORADO,SCH MED,DENVER,CO 80202

来源：

NEUROLOGY | 1991年 / 41卷 / 09期

关键词：

D O I：

10.1212/WNL.41.9.1349

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Gadolinium (Gd) enhancement of brain lesions by MRI is a marker of active blood-brain barrier damage secondary to an inflammatory process. We studied the effects of high-dose (1,000 mg/d) intravenous (IV) methylprednisolone (Mp) for 4 to 8 days on Gd-enhancing lesions in seven patients with acute demyelinating diseases and compared pretreatment brain MRIs with studies obtained 1 to 4 days after treatment. Five patients had complete suppression, and two had significant suppression of Gd enhancement following treatment. In addition, six of seven patients had Gd-enhancing lesions that explained their clinical signs; in five of six of these patients, suppression of the Gd-enhanced lesions temporally correlated with clinical improvement. Thus, short courses of high-dose IV Mp suppress Gd enhancement in acute demyelinating lesions, and this correlates with clinical improvement.

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页码：1349 / 1354

页数：6

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