STUDY AND OPTIMIZATION OF COLUMN EFFICIENCY IN HPLC - COMPARISON OF 2 METHODS FOR SEPARATING 10 BENZODIAZEPINES

被引：15

作者：

GUILLAUME, Y

GUINCHARD, C

机构：

[1] Laboratoire de Chintie Arudytique, UFR des Sciences M&dicales et Pharmaceutinues, Place St Jacques, Besan$on

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1994年 / 17卷 / 07期

关键词：

D O I：

10.1080/10826079408013172

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

To understand the influence of mobile phase composition, its now rate and column temperature involved in high performance Liquid Chromatography, an experimental design was used. The observed responses were the theoretical plate number, the linear velocity of the mobile phase and a new chromatographic resolution function which provided the most efficient separation of ten compounds as ten benzodiazepines. Optimum conditions obtained were compared with another optimization method.

引用

页码：1443 / 1459

页数：17

共 17 条

[1] UNATTENDED OPTIMIZATION OF NORMAL PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY SEPARATIONS WITH A MICROCOMPUTER CONTROLLED CHROMATOGRAPH [J].

BERRIDGE, JC .

CHROMATOGRAPHIA, 1982, 16 :172-174

[2]

BERRIDGE JC, 1982, J CHROMATOGR, V1, P244

[3]

BERRIDGE JC, 1984, J CHROMATOGR, V69, P316

[4] CRISEBOOK, A HYPERMEDIA VERSION OF AN EXPERT SYSTEM FOR THE SELECTION OF OPTIMIZATION CRITERIA IN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

BOURGUIGNON, B ;

VANKEERBERGHEN, P ;

MASSART, DL .

JOURNAL OF CHROMATOGRAPHY, 1992, 592 (1-2) :51-57

[5]

Box G. E. P., 1960, TECHNOMETRICS, V2, P455, DOI [10.2307/1266454, DOI 10.2307/1266454, 10.1080/00401706.1960.10489912, DOI 10.1080/00401706.1960.10489912]

[6] ON THE EXPERIMENTAL ATTAINMENT OF OPTIMUM CONDITIONS [J].

BOX, GEP ;

WILSON, KB .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1951, 13 (01) :1-45

[7]

Christophe A.B., 1971, CHROMATOGRAPHIA, V4, P455, DOI DOI 10.1007/BF02268814

[8]

DEMING SN, 1979, CLIN CHEM, V25, P840

[9]

ELFALLAH MZ, 1988, ANALUSIS, V16, P241

[10] COMPUTER-AIDED OPTIMIZATION OF DRUG ENANTIOMER SEPARATION IN CHIRAL HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].

FELL, AF ;

NOCTOR, TAG ;

MAMA, JE ;

CLARK, BJ .

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1988, 434 (02) :377-384

← 1 2 →