NOVEL CA2+-ATPASE INHIBITORS FROM THE DRIED ROOT TUBERS OF POLYGONUM-MULTIFLORUM

被引：31

作者：

GRECH, JN ^{[1
]}

LI, Q ^{[1
]}

ROUFOGALIS, BD ^{[1
]}

DUKE, CC ^{[1
]}

机构：

[1] UNIV SYDNEY, DEPT PHARM, SYDNEY, NSW 2006, AUSTRALIA

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 12期

关键词：

D O I：

10.1021/np50114a010

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The MeOH extract of the dried root tubers of Polygonum multiflorum yielded three bioactive compounds with an inhibitory activity on calmodulin-depleted erythrocyte calcium-dependent ATPase. These compounds were identified as E-2,3,5,4'-tetrahydroxystilbene 2-O-beta-D-glucopyranoside [2] (IC50=240 mu M) and cis- and trans-E-3-butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-1(3H)-isobenzofuranone [3 and 4] (IC50=160 and 260 mu M, respectively). E-2,4,6,4'-Tetrahydroxystilbene 2-O-beta-D-glucopyranoside [1] was also isolated but was found to have no inhibitory effect on the enzyme.

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页码：1682 / 1687

页数：6

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