SERIAL CA-125 LEVELS DURING CHEMOTHERAPY FOR METASTATIC OR RECURRENT ENDOMETRIAL CANCER

被引:23
作者
FANNING, J [1 ]
PIVER, MS [1 ]
机构
[1] ROSWELL PK CANC INST,DEPT GYNECOL ONCOL,BUFFALO,NY
关键词
D O I
10.1097/00006250-199102000-00024
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The purpose of this study was to evaluate the role of serial CA 125 in monitoring disease status during chemotherapy in women with metastatic or recurrent endometrial cancer. CA 125 was measured in 21 women receiving cisplatin, etoposide, and Adriamycin for a total of 275 courses of chemotherapy (median eight). Eight of ten patients had elevated pre-therapy CA 125 levels (median 233 U/mL). CA 125 became and/or remained negative in all 20 women with responding or stable disease and was elevated in all nine patients who relapsed. The median level at the time of relapse was 56 U/mL. Levels were elevated before clinical relapse in five of nine patients (56%). Serial CA 125 may aid in the management of women receiving chemotherapy for advanced or recurrent endometrial cancer.
引用
收藏
页码:278 / 280
页数:3
相关论文
共 4 条
[1]   A RADIOIMMUNOASSAY USING A MONOCLONAL-ANTIBODY TO MONITOR THE COURSE OF EPITHELIAL OVARIAN-CANCER [J].
BAST, RC ;
KLUG, TL ;
STJOHN, E ;
JENISON, E ;
NILOFF, JM ;
LAZARUS, H ;
BERKOWITZ, RS ;
LEAVITT, T ;
GRIFFITHS, CT ;
PARKER, L ;
ZURAWSKI, VR ;
KNAPP, RC .
NEW ENGLAND JOURNAL OF MEDICINE, 1983, 309 (15) :883-887
[2]  
LAVIN PT, 1987, OBSTET GYNECOL, V69, P223
[3]   ELEVATION OF SERUM CA125 IN CARCINOMAS OF THE FALLOPIAN-TUBE, ENDOMETRIUM, AND ENDOCERVIX [J].
NILOFF, JM ;
KLUG, TL ;
SCHAETZL, E ;
ZURAWSKI, VR ;
KNAPP, RC ;
BAST, RC .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1984, 148 (08) :1057-1058
[4]  
PATSNER B, 1989, European Journal of Gynaecological Oncology, V10, P322