11Q23 ABNORMALITIES IN CHILDREN WITH ACUTE NONLYMPHOCYTIC LEUKEMIA (M4-M5) - ASSOCIATION WITH PREVIOUS CHEMOTHERAPY

被引：51

作者：

PRIETO, F ^{[1
]}

PALAU, F ^{[1
]}

BADIA, L ^{[1
]}

BENEYTO, M ^{[1
]}

PEREZSIRVENT, ML ^{[1
]}

ORTS, A ^{[1
]}

CASTEL, V ^{[1
]}

机构：

[1] HOSP LA FE,UNIDAD ONCOL PEDIAT,VALENCIA,SPAIN

来源：

CANCER GENETICS AND CYTOGENETICS | 1990年 / 45卷 / 01期

关键词：

D O I：

10.1016/0165-4608(90)90061-E

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic studies of 12 patients aged less than 14 years with acute nonlymphoblastic leukemia (ANLL) (M4-M5) showed structural abnormalities on chromosome 11 at band q23-q24 in five cases (41.8%). Four of these 12 patients had ANLL (M4-M5) after treatment with cytostatics for non-Hodgkin lymphoma in one case and for an acute lymphoblastic leukemia (ALL) in the other three. Three of these four cases had 11q23 abnormalities [one 46,XY,t(11;17)(q23;25); another 47,XY,+8,-15,del(11)(q23),+der(15)t(15;?)(p11;?); the third 47,XX,+8,t(3;17) (p11;q25),t(4;11)(q21;q23)] and one had a normal karyotype on being diagnosed ANLL (M4-M5). The notable increase of ANLL (M4-M5) in our patients who had received cytostatics as treatment for a previous neoplasia makes evaluation of our results timely in comparison with those of other groups who use these therapeutic protocols. © 1990.

引用

收藏

页码：1 / 11

页数：11

相关论文

共 33 条

[1] SIGNIFICANCE OF ABNORMALITIES INVOLVING CHROMOSOMAL SEGMENT 11Q22-25 IN ACUTE-LEUKEMIA [J].

ABE, R ;

SANDBERG, AA .

CANCER GENETICS AND CYTOGENETICS, 1984, 13 (02) :121-127

[2] PROPOSED REVISED CRITERIA FOR THE CLASSIFICATION OF ACUTE MYELOID-LEUKEMIA - A REPORT OF THE FRENCH-AMERICAN-BRITISH COOPERATIVE GROUP [J].

BENNETT, JM ;

CATOVSKY, D ;

DANIEL, MT ;

FLANDRIN, G ;

GALTON, DAG ;

GRALNICK, HR ;

SULTAN, C .

ANNALS OF INTERNAL MEDICINE, 1985, 103 (04) :620-625

[3] ACUTE MONOCYTIC LEUKEMIA CHROMOSOME-STUDIES [J].

BERGER, R ;

BERNHEIM, A ;

SIGAUX, F ;

DANIEL, MT ;

VALENSI, F ;

FLANDRIN, G .

LEUKEMIA RESEARCH, 1982, 6 (01) :17-26

[4] CYTOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC LEUKEMIA IN 73 CHILDREN AND ADOLESCENTS [J].

BRODEUR, GM ;

WILLIAMS, DL ;

KALWINSKY, DK ;

WILLIAMS, KJ ;

DAHL, GV .

CANCER GENETICS AND CYTOGENETICS, 1983, 8 (02) :93-105

[5] TRISOMY OF THE LONG ARM OF CHROMOSOME-1 IN PATIENTS WITH HEMATOLOGIC MALIGNANCIES AND SOLID TUMORS - REPORT OF 6 CASES [J].

CERVANTES, F ;

PRIETO, F ;

BADIA, L ;

ORTS, A .

CANCER GENETICS AND CYTOGENETICS, 1988, 31 (02) :165-170

[6] CHROMOSOMAL LOCALIZATION OF THE HUMAN PROTO-ONCOGENE C-ETS [J].

DETAISNE, C ;

GEGONNE, A ;

STEHELIN, D ;

BERNHEIM, A ;

BERGER, R .

NATURE, 1984, 310 (5978) :581-583

[7] A POSSIBLE SPECIFIC CHROMOSOME MARKER FOR MONOCYTIC LEUKEMIA - 3 MORE PATIENTS WITH T(9-11)(P22-Q24) AND ANOTHER WITH T(11-17)(Q24-Q21), EACH WITH ACUTE MONOBLASTIC LEUKEMIA [J].

DEWALD, GW ;

MORRISONDELAP, SJ ;

SCHUCHARD, KA ;

SPURBECK, JL ;

PIERRE, RV .

CANCER GENETICS AND CYTOGENETICS, 1983, 8 (03) :203-212

[8] INTERFERON AND C-ETS-1 GENES IN THE TRANSLOCATION (9-11)(P22-Q23) IN HUMAN ACUTE MONOCYTIC LEUKEMIA [J].

DIAZ, MO ;

LEBEAU, MM ;

PITHA, P ;

ROWLEY, JD .

SCIENCE, 1986, 231 (4735) :265-267

[9] A 2P-11Q CHROMOSOME-TRANSLOCATION IN DYSMYELOPOIETIC PRELEUKEMIA [J].

FEDER, M ;

FINAN, J ;

BESA, E ;

NOWELL, P .

CANCER GENETICS AND CYTOGENETICS, 1985, 15 (1-2) :143-150

[10] HYBRID ACUTE-LEUKEMIA [J].

GALE, RP ;

BENBASSAT, I .

BRITISH JOURNAL OF HAEMATOLOGY, 1987, 65 (03) :261-264

← 1 2 3 4 →