PROTEOLYTIC ACTIVITY IN MOUSE URINE - RELATIONSHIP TO THE KIDNEY METALLOENDOPEPTIDASE, MEPRIN

被引：9

作者：

FLANNERY, AV ^{[1
]}

DALZELL, GN ^{[1
]}

BEYNON, RJ ^{[1
]}

机构：

[1] UNIV LIVERPOOL, DEPT BIOCHEM, PROTEOLYSIS RES GRP, POB 147, LIVERPOOL L69 3BX, ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1041卷 / 01期

关键词：

(Human); Fibrin; Kinetics; Tissue-type plasminogen activator;

D O I：

10.1016/0167-4838(90)90123-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Meprin, a brush border kidney metallo-endopeptidase is present as the major endopeptidase in mouse urine. The enzyme is freely soluble and can be detected enzymically or immunologically. Mice can be partitioned into two phenotypes that differ by 10-20-fold in the amount of meprin in kidney membranes; this phenotypic variation is reflected in urinary activities. We propose a role for meprin in the degradation of other urinary proteins. © 1990.

引用

页码：64 / 70

页数：7

共 30 条

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