THE VASCULARITY OF PRIMARY CUTANEOUS MELANOMA

被引:79
作者
FALLOWFIELD, ME
COOK, MG
机构
[1] Department of Histopathology, St George's Hospital Medical School, London, SW170RE, Cranmer Terrace
[2] Department of Histopathology, Royal Surrey County Hospital, Guildford, Surrey
关键词
MELANOMA; VASCULARITY; MICROCIRCULATION;
D O I
10.1002/path.1711640309
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In primary cutaneous malignant melanoma, the vascularity of the dermis immediately deep to the lesion may relate to tumour aggressiveness and to prognosis. These newly formed dermal vessels are incorporated into the melanoma to form the tumour microcirculation. We have assessed the percentage vascular volume in a series of primary melanomas in order to investigate the relationship between tumour vascularity and maximum tumour thickness. For the 64 melanomas included in this study, there appeared to be a significant relationship between the percentage vascular volume and the maximum tumour thickness. This relationship was not influenced by the presence of necrosis, vascular invasion, regression, or lymphocytic infiltrate, nor by the growth phase of the tumour. However, the percentage vascular volume was very low in the occasional thick melanoma, at least one of which was associated with prolonged survival. It seems possible that a low tumour vascularity could correlate with a relatively favourable outcome in cutaneous melanoma.
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页码:241 / 244
页数:4
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