LACK OF PHARMACOKINETIC INTERACTION BETWEEN INTRAVENOUS 2',3'-DIDEOXYINOSINE AND 3'-AZIDO-3'-DEOXYTHYMIDINE IN RATS

被引：20

作者：

WIENTJES, MG

AU, JLS

机构：

[1] OHIO STATE UNIV,CTR COMPREHENS CANC,COLUMBUS,OH 43210

[2] OHIO STATE UNIV,COLL PHARM,COLUMBUS,OH 43210

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 03期

关键词：

D O I：

10.1128/AAC.36.3.665

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We investigated the pharmacokinetic interaction between 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxyinosine (ddI), given to rats by intravenous injection. For both compounds, the clearances, terminal half-lives, and fractions of the dose excreted unchanged in urine were not altered by the other drug (P > 0.05), indicating no pharmacokinetic interaction between the two drugs.

引用

页码：665 / 668

页数：4

共 21 条

[1]

AGARWAL RP, 1988, P AM ASSOC CANC RES, V29, P347

[2]

AUGUST EM, 1991, MOL PHARMACOL, V39, P246

[3] STATISTICAL ESTIMATIONS IN PHARMACOKINETICS [J].

BOXENBAU.HG ;

RIEGELMA.S ;

ELASHOFF, RM .

JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS, 1974, 2 (02) :123-148

[4] DIDEOXYINOSINE IN CHILDREN WITH SYMPTOMATIC HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION [J].

BUTLER, KM ;

HUSSON, RN ;

BALIS, FM ;

BROUWERS, P ;

EDDY, J ;

ELAMIN, D ;

GRESS, J ;

HAWKINS, M ;

JAROSINSKI, P ;

MOSS, H ;

POPLACK, D ;

SANTACROCE, S ;

VENZON, D ;

WIENER, L ;

WOLTERS, P ;

PIZZO, PA .

NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (03) :137-144

[5] INITIAL STUDIES ON THE CELLULAR PHARMACOLOGY OF 2',3'-DIDEOXYADENOSINE, AN INHIBITOR OF HTLV-III INFECTIVITY [J].

COONEY, DA ;

AHLUWALIA, G ;

MITSUYA, H ;

FRIDLAND, A ;

JOHNSON, M ;

HAO, Z ;

DALAL, M ;

BALZARINI, J ;

BRODER, S ;

JOHNS, DG .

BIOCHEMICAL PHARMACOLOGY, 1987, 36 (11) :1765-1768

[6] PHOSPHORYLATION OF 3'-AZIDO-3'-DEOXYTHYMIDINE AND SELECTIVE INTERACTION OF THE 5'-TRIPHOSPHATE WITH HUMAN-IMMUNODEFICIENCY-VIRUS REVERSE-TRANSCRIPTASE [J].

FURMAN, PA ;

FYFE, JA ;

STCLAIR, MH ;

WEINHOLD, K ;

RIDEOUT, JL ;

FREEMAN, GA ;

LEHRMAN, SN ;

BOLOGNESI, DP ;

BRODER, S ;

MITSUYA, H ;

BARRY, DW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (21) :8333-8337

[7]

GRIFFITHS DA, 1991, J PHARMACOL EXP THER, V257, P149

[8]

JOHNSON MA, 1989, MOL PHARMACOL, V36, P291

[9] PLASMA AND CEREBROSPINAL-FLUID PHARMACOKINETICS OF 3'-AZIDO-3'-DEOXYTHYMIDINE - A NOVEL PYRIMIDINE ANALOG WITH POTENTIAL APPLICATION FOR THE TREATMENT OF PATIENTS WITH AIDS AND RELATED DISEASES [J].

KLECKER, RW ;

COLLINS, JM ;

YARCHOAN, R ;

THOMAS, R ;

JENKINS, JF ;

BRODER, S ;

MYERS, CE .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1987, 41 (04) :407-412

[10] PHARMACOKINETICS OF DIDANOSINE IN PATIENTS WITH ACQUIRED-IMMUNODEFICIENCY-SYNDROME OR ACQUIRED-IMMUNODEFICIENCY-SYNDROME RELATED COMPLEX [J].

KNUPP, CA ;

SHYU, WC ;

DOLIN, R ;

VALENTINE, FT ;

MCLAREN, C ;

MARTIN, RR ;

PITTMAN, KA ;

BARBHAIYA, RH .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 1991, 49 (05) :523-535

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