PALLADIUM-CATALYZED COUPLING OF TERMINAL ALKYNES TO THE FREE CIS-DIOL METABOLITE PRODUCED FROM THE OXIDATION OF BROMOBENZENE BY PSEUDOMONAS-PUTIDA - SYNTHESIS OF NEW HOMOCHIRAL 3-ALKYNYL CIS-CYCLOHEXA-3,5-DIENE-1,2-DIOLS

被引：11

作者：

HUDLICKY, T

BOROS, EE

机构：

[1] Virginia Polytechnic Institute, State University Blacksburg

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0957-4166(00)80194-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The free cis-diol metabolite (1) produced from the oxidation of bromobenzene by Pseudomonas putida underwent Pd(0)-catalyzed coupling with trimethylsilyl acetylene, phenylacetylene and 1-hexyne providing the novel homochiral (1S, 2R)-3-alkynyl cis-cyclohexa-3,5-diene-1,2-diols 2-4 in good to excellent yields.

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页码：217 / 220

页数：4

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