LEVAMISOLE, THE STORY AND THE LESSONS

被引:65
作者
AMERY, WKP
BRUYNSEELS, JPJM
机构
[1] Janssen Research Foundation
来源
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1992年 / 14卷 / 03期
关键词
D O I
10.1016/0192-0561(92)90179-O
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The history of the use of levamisole in man is summarized, from its start as an anthelmintic in the early sixties, through its world-wide recognition as an immunotropic agent especially in the seventies and early eighties, and its return to clinical prominence in 1989-90 as an effective adjuvant treatment for operable colon cancer. The knowledge accumulated from experimental tumour models and from clinical use in various types of cancer, supplemented with the recent evidence obtained from large-scale controlled trials in resectable colon cancer is reviewed. It is speculated that we may not have seen the end of levamisole story yet; also, the role of serendipity in drug research is emphasized.
引用
收藏
页码:481 / 486
页数:6
相关论文
共 27 条
[1]   LEVAMISOLE AND IMMUNOTHERAPY - SOME THEORETIC AND PRACTICAL CONSIDERATIONS AND THEIR RELEVANCE TO HUMAN-DISEASE [J].
AMERY, WK ;
GOUGH, DA .
ONCOLOGY, 1981, 38 (03) :168-181
[2]   ADJUVANT TREATMENT WITH LEVAMISOLE IN CANCER - REVIEW OF EXPERIMENTAL AND CLINICAL DATA [J].
AMERY, WK ;
SPREAFICO, F ;
ROJAS, AF ;
DENISSEN, E ;
CHIRIGOS, MA .
CANCER TREATMENT REVIEWS, 1977, 4 (03) :167-194
[3]   THE DOSAGE REGIMEN OF LEVAMISOLE IN CANCER - IS IT RELATED TO EFFICACY AND SAFETY [J].
AMERY, WK ;
BUTTERWORTH, BS .
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1983, 5 (01) :1-9
[4]  
AMERY WK, 1982, IMMUNOTHERAPY HUMAN, P123
[5]  
CHIRIGOS MA, 1973, CANCER RES, V33, P2615
[6]  
Janssen P A, 1976, Prog Drug Res, V20, P347
[7]  
KLEFSTROM P, 1985, CANCER, V55, P2753, DOI 10.1002/1097-0142(19850615)55:12<2753::AID-CNCR2820551204>3.0.CO
[8]  
2-Q
[9]   PURIFICATION, CHARACTERIZATION, AND STRUCTURAL ELUCIDATION OF THE ACTIVE MOIETY OF THE PREVIOUSLY CALLED SUPPRESSOR ACTIVATING FACTOR (SAF) [J].
LAU, C ;
STANOJEV, D ;
VISCONTI, V ;
PANG, H ;
KREPINSKY, G ;
GREY, A ;
WANG, E ;
ISHAQUE, A .
CELLULAR IMMUNOLOGY, 1990, 125 (01) :92-106
[10]   SURGICAL ADJUVANT THERAPY OF LARGE-BOWEL CARCINOMA - AN EVALUATION OF LEVAMISOLE AND THE COMBINATION OF LEVAMISOLE AND FLUOROURACIL [J].
LAURIE, JA ;
MOERTEL, CG ;
FLEMING, TR ;
WIEAND, HS ;
LEIGH, JE ;
RUBIN, J ;
MCCORMACK, GW ;
GERSTNER, JB ;
KROOK, JE ;
MALLIARD, J ;
TWITO, DI ;
MORTON, RF ;
TSCHETTER, LK ;
BARLOW, JF .
JOURNAL OF CLINICAL ONCOLOGY, 1989, 7 (10) :1447-1456