A PRACTICAL CONVERGENT ROUTE TO (23S,25R)-1-ALPHA,25-DIHYDROXYVITAMIN-D3 26,23-LACTONE

被引：8

作者：

HATAKEYAMA, S ^{[1
]}

SUGAWARA, M ^{[1
]}

KAWAMURA, M ^{[1
]}

TAKANO, S ^{[1
]}

机构：

[1] TOHOKU UNIV,INST PHARMACEUT,SENDAI,MIYAGI 980,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 17期

关键词：

D O I：

10.1039/c39920001229

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Ireland-Claisen rearrangement of the lactate 8, prepared from the Inhoffen-Lythgoe diol 5, followed by iodolactonisation allowed easy access to the C-D-ring fragment 4, from which a novel convergent synthesis of (23S,25R)-1-alpha,25-dihydroxyvitamin D3 26,23-lactone 1 has been accomplished via coupling with the A-ring fragment 3.

引用

收藏

页码：1229 / 1231

页数：3

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