EFFICIENT ASYMMETRIC-SYNTHESIS OF AMINO-ACIDS THROUGH HYDROGENATION OF THE DIDEHYDROAMINO ACID RESIDUE IN CYCLIC IMINO-ESTER DERIVATIVES

被引：26

作者：

CATIVIELA, C

DIAZDEVILLEGAS, MD

GALVEZ, JA

机构：

[1] Instituto de Ciencia de Materiales de Aragón, Departamento de Quimica Orgánica, Universidad de Zaragoza-C.S.I.C.

来源：

TETRAHEDRON-ASYMMETRY | 1992年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0957-4166(00)80263-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The trisubstituted olefinic bond of chiral cyclic alpha,beta-didehydroamino acid derivatives was hydrogenated in the presence of Pd/C with > 95% diastereoface discrimination to give, after hydrolysis, the corresponding S-amino acids. The reduction of the double bond with L-selectride(R) does not change the orientation of diastereoface discrimination and the diastereoselectivity is still high.

引用

页码：567 / 572

页数：6

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