FUNCTION SPECIFIC SUPERSENSITIVITY OF M-CHLOROPHENYL PIPERAZINE-INDUCED SEROTONERGIC NEUROTRANSMISSION IN FEMALE COMPARED TO MALE-RATS

被引：18

作者：

HALEEM, DJ ^{[1
]}

机构：

[1] UNIV KARACHI, BIOCHEM NEUROPHARMACOL UNIT, KARACHI 75270, PAKISTAN

来源：

LIFE SCIENCES | 1993年 / 52卷 / 25期

关键词：

D O I：

10.1016/0024-3205(93)90693-W

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Administration of various doses of m-chlorophenylpiperazine (m-CPP), a 5-hydroxytryptamine (5-HT) agonist, to rats increased plasma levels of corticosterone and decreased locomotor activity in a dose dependent manner. The increases of plasma corticosterone but not the decreases of locomotor activity were greater in female than male rats. Hypophagic effects of m-CPP not different in freely feeding male and female rats were greater in females when food deprived animals used. The findings along with our previous report show a functional supersensitivity of 5-HT neurotransmission involved in the regulation of hypothalamo-pituitary adrenocortical axis and appetite supression in female sex, and suggest a possible basis for the greater occurence of depression and anorexia in women than men.

引用

页码：PL279 / PL284

页数：6

共 22 条

[1] SEROTONIN AGONISTS CAUSE PARALLEL ACTIVATION OF THE SYMPATHOADRENOMEDULLARY SYSTEM AND THE HYPOTHALAMO-PITUITARY-ADRENOCORTICAL AXIS IN CONSCIOUS RATS [J].