DOCKING SMALL-MOLECULE LIGANDS INTO ACTIVE-SITES

被引：79

作者：

JONES, G ^{[1
]}

WILLETT, P ^{[1
]}

机构：

[1] UNIV SHEFFIELD, DEPT INFORMAT STUDIES, WESTERN BANK, SHEFFIELD S10 2TN, S YORKSHIRE, ENGLAND

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1995年 / 6卷 / 06期

关键词：

D O I：

10.1016/0958-1669(95)80107-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Docking involves the development of computer algorithms that evaluate the binding modes of putative ligands in receptor sites. The principal advances of the past year have been the development of new algorithmic approaches, several of which incorporate conformational flexibility, and the increased use of docking to identify leads in drug-discovery programmes.

引用

页码：652 / 656

页数：5

共 28 条

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