STABILITY OF ISRADIPINE IN AN EXTEMPORANEOUSLY COMPOUNDED ORAL LIQUID

被引:20
作者
MACDONALD, JL
JOHNSON, CE
JACOBSON, P
机构
[1] UNIV MICHIGAN,COLL PHARM,ANN ARBOR,MI 48109
[2] MIAMI CHILDRENS HOSP,DEPT PHARM,MIAMI,FL
[3] UNIV MICHIGAN,MED CTR,ANN ARBOR,MI
来源
AMERICAN JOURNAL OF HOSPITAL PHARMACY | 1994年 / 51卷 / 19期
关键词
COMPOUNDING; HYPOTENSIVE AGENTS; INCOMPATIBILITIES; ISRADIPINE; STABILITY; STORAGE; SUCROSE; SUSPENSIONS; TABLETS; VEHICLES;
D O I
10.1093/ajhp/51.19.2409
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The stability of isradipine in an extemporaneously compounded oral liquid was studied. A suspension was prepared from the powder of commercially available 5-mg isradipine capsules and sufficient Simple Syrup, NF, to make a final volume of 50 mL. A control suspension was prepared from analytical-grade isradipine powder and Simple Syrup, NF. The final concentration of isradipine in both suspensions was 1 mg/mL. Three identical volumes of each suspension were stored in 2-oz amber glass prescription bottles, which were stored at 4 degrees C. Immediately after preparation and at 7, 16, 22, 28, and 35 days, samples were visually inspected and assayed in duplicate by high-performance liquid chromatography; the pH of the samples was also determined. At least 95% of the initial isradipine concentration remained throughout the study period in all samples of both suspensions. Color, odor, and pH did not change appreciably. Isradipine 1 mg/mL in an oral liquid compounded from Simple Syrup, NF, and powder from capsules was stable for at least 35 days in amber glass bottles at 4 degrees C.
引用
收藏
页码:2409 / 2411
页数:3
相关论文
共 14 条
  • [1] HYPERTENSION AFTER RENAL-TRANSPLANTATION
    BACHY, C
    ALEXANDRE, GPJ
    VANYPERSELEDESTRIHOU, C
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 1976, 2 (6047): : 1287 - 1289
  • [2] EFFECTS OF ISRADIPINE ON RENAL-FUNCTION IN CYCLOSPORINE-TREATED RENAL TRANSPLANTED PATIENTS
    BERG, KJ
    HOLDAAS, H
    ENDRESEN, L
    FAUCHALD, P
    HARTMANN, A
    PRAN, T
    SOLBU, D
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 1991, 6 (10) : 725 - 730
  • [3] CHAPMAN JR, 1987, TRANSPLANTATION, V43, pS60
  • [4] DAWIDSON I, 1989, TRANSPLANTATION, V48, P575
  • [5] LACK OF EFFECT OF THE CALCIUM-ANTAGONIST ISRADIPINE ON CYCLOSPORINE PHARMACOKINETICS IN RENAL-TRANSPLANT PATIENTS
    ENDRESEN, L
    BERGAN, S
    HOLDAAS, H
    PRAN, T
    SINDINGLARSEN, B
    BERG, KJ
    [J]. THERAPEUTIC DRUG MONITORING, 1991, 13 (06) : 490 - 495
  • [6] DOES NIFEDIPINE AMELIORATE CYCLOSPORINE-A NEPHROTOXICITY
    FEEHALLY, J
    WALLS, J
    MISTRY, N
    HORSBURGH, T
    TAYLOR, J
    VEITCH, PS
    BELL, PRF
    [J]. BRITISH MEDICAL JOURNAL, 1987, 295 (6593) : 310 - 310
  • [7] STABILITY OF AN EXTEMPORANEOUSLY COMPOUNDED TERBUTALINE SULFATE ORAL LIQUID
    HORNER, RK
    JOHNSON, CE
    [J]. AMERICAN JOURNAL OF HOSPITAL PHARMACY, 1991, 48 (02): : 293 - 295
  • [8] CYCLOSPORINE-INDUCED RENAL DYSFUNCTION IN HUMAN RENAL-ALLOGRAFT RECIPIENTS
    KIBERD, BA
    [J]. TRANSPLANTATION, 1989, 48 (06) : 965 - 969
  • [9] LATE MORTALITY AND MORBIDITY IN RECIPIENTS OF LONG-TERM RENAL-ALLOGRAFTS
    KIRKMAN, RL
    STROM, TB
    WEIR, MR
    TILNEY, NL
    [J]. TRANSPLANTATION, 1982, 34 (06) : 347 - 351
  • [10] PROPPER DJ, 1989, CLIN NEPHROL, V32, P62