Study of the impact of perilipin polymorphisms in a French population

被引：19

作者：

Meirhaeghe, Aline ^{[1
,2
,3
]}

Thomas, Severine ^{[1
,2
,3
]}

Ancot, Frederic ^{[1
,2
,3
]}

Cottel, Dominique ^{[1
,2
,3
]}

Arveiler, Dominique ^{[4
]}

Ferrieres, Jean ^{[5
]}

Amouyel, Philippe ^{[1
,2
,3
]}

机构：

[1] INSERM, U744, Lille, France

[2] Inst Pasteur, Lille, France

[3] Univ Lille 2, Lille, France

[4] Fac Med, Dept Epidemiol & Publ Hlth, Strasbourg, France

[5] INSERM, Fac Med, U558, Toulouse, France

来源：

JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE | 2006年 / 5卷

关键词：

D O I：

10.1186/1477-5751-5-10

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Background: Perilipins are proteins localized at the surface of the lipid droplet in adipocytes, steroid-producing cells and ruptured atherosclerotic plaques playing a role in the regulation of triglyceride deposition and mobilization. We investigated whether perilipin gene polymorphisms were associated with obesity, type 2 diabetes, and their related variables (anthropometric variables, plasma leptin, lipids, glucose and insulin concentrations) in a cross-sectional random sample of 1120 French men and women aged 35 to 65 years old, including 227 obese (BMI >= 30 kg/m(2)) and 275 type 2 diabetes subjects. Results: Among 7 perilipin polymorphisms tested, only 2 (rs4578621 and rs894160) of them were frequent enough to be fully investigated and we genotyped the sample using the PCR-RFLP method. No significant associations could be found between any of these polymorphisms and the studied phenotypes. Conclusion: The rs4578621 and rs894160 polymorphisms of the perilipin gene are not major genetic determinants of obesity and type 2 diabetes-related phenotypes in a random sample of French men and women.

引用

页数：6

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