HEPATIC INFLUENCE ON SPLENIC SYNTHESIS AND RELEASE OF COAGULATION ACTIVITIES

被引:21
作者
DODDS, WJ
机构
[1] Division of Laboratories and Research, New York State Department of Health, Albany
关键词
D O I
10.1126/science.166.3907.882
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Isolated rabbit liver perfusates contain one or more puromycin-sensitive factors that stimulate factor VIII and IX activities in splenic perfusates. Production of coagulation activity by a complementary process involving organ perfusates suggests existence of coagulation factor precursors. An analogy is made to appearance of high factor VIII activity after plasma transfusions in von Willebrands disease.
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页码:882 / &
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