INCREASED INVITRO SENSITIVITY OF CANDIDA-ALBICANS TO FLUCONAZOLE

被引：17

作者：

SIMONETTI, N

DAURIA, FD

STRIPPOLI, V

机构：

[1] Istituto di Microbiologia, Facolta di Farmacia, Univ. di Roma 'La Sapienza', I-00185 Roma, Piazzale A. Moro

来源：

CHEMOTHERAPY | 1991年 / 37卷 / 01期

关键词：

FLUCONAZOLE; INCREASED ACTIVITY INVITRO; SODIUM DIOCTYLSULFOSUCCINATE; SURFACTANT; MINIMUM INHIBITORY CONCENTRATION;

D O I：

10.1159/000238829

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sodium dioctyl sulfosuccinate (SDSS), an anionic surfactant used at a non-antimicrobial concentration, increased the sensitivity of Candida albicans to fluconazole in complex media (such as Sabouraud). The conditions were assessed to determine the in vitro sensitivity to fluconazole. In this connection, the use of a liquid medium at a non-alkaline pH is important. The presence of SDSS in complex media does not seem to affect the neutralization of a particular substances but favours the activity of fluconazole.

引用

页码：32 / 37

页数：6

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