REACTION OF THE OCTAHEDRAL ANTITUMOR COMPLEX TRANS-RUCL2(DMSO)4 WITH 2'DEOXYGUANOSINE

被引：25

作者：

CAUCI, S

VIGLINO, P

ESPOSITO, G

QUADRIFOGLIO, F

机构：

[1] Institute of Biology, School of Medicine, University of Udine, Udine

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1991年 / 43卷 / 04期

关键词：

D O I：

10.1016/0162-0134(91)80045-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The reaction of the antitumor octahedral complex trans-RuCl2(DMSO)4 with 2'deoxyguanosine leads to the reversible formation of two diastereoisomeric monoadducts and one biadduct. This shows that it is possible to accomodate two purine bases in a cis configuration in an octahedral transition metal complex which exhibits antiblastic activity. All the product compounds are characterized by a guanine moiety coordination via the N7 atom. A marked decrease (about two pK units) is observed for the N1H pKa of the coordinated guanine moieties. The reversibility of the monodentate binding could explain the low toxicity of the ruthenium(II) complexes.

引用

收藏

页码：739 / 751

页数：13

相关论文

共 25 条

[1] NOVEL DIASTEREOMERS WITH OPPOSITE CHIRALITY AT RUTHENIUM FORMED BY N7, ALPHA-PO4 CHELATION OF 5'-DGMP TO THE ANTIMETASTATIC AGENT TRANS-RUCL2(DMSO)4 - NMR AND CD EVIDENCE [J].

ALESSIO, E ;

XU, YH ;

CAUCI, S ;

MESTRONI, G ;

QUADRIFOGLIO, F ;

VIGLINO, P ;

MARZILLI, LG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (18) :7068-7071

[2] CIS-DIHALOTETRAKIS(DIMETHYL SULFOXIDE)RUTHENIUM(II) AND TRANS-DIHALOTETRAKIS(DIMETHYL SULFOXIDE)RUTHENIUM(II) COMPLEXES (RUX2(DMSO)4, X = CL, BR) - SYNTHESIS, STRUCTURE, AND ANTITUMOR-ACTIVITY [J].

ALESSIO, E ;

MESTRONI, G ;

NARDIN, G ;

ATTIA, WM ;

CALLIGARIS, M ;

SAVA, G ;

ZORZET, S .

INORGANIC CHEMISTRY, 1988, 27 (23) :4099-4106

[3]

ALESSIO E, 1987, PLATINUM OTHER METAL, P617

[4] STRUCTURE OF [PT(EN)(5'-GMP)2]2- ANION [J].

BAU, R ;

GELLERT, RW .

BIOCHIMIE, 1978, 60 (09) :1040-1040

[5] MLEV-17-BASED TWO-DIMENSIONAL HOMONUCLEAR MAGNETIZATION TRANSFER SPECTROSCOPY [J].

BAX, A ;

DAVIS, DG .

JOURNAL OF MAGNETIC RESONANCE, 1985, 65 (02) :355-360

[6] STRUCTURE DETERMINATION OF A TETRASACCHARIDE - TRANSIENT NUCLEAR OVERHAUSER EFFECTS IN THE ROTATING FRAME [J].

BOTHNERBY, AA ;

STEPHENS, RL ;

LEE, JM ;

WARREN, CD ;

JEANLOZ, RW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (03) :811-813

[7] OCTAHEDRAL COMPLEXES OF ANTI-CANCER PT(IV)(CYCLOHEXYLDIAMINE) AGENTS WITH 9-METHYLGUANINE [J].

CHOI, HK ;

HUANG, SKS ;

BAU, R .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 156 (03) :1125-1129

[8]

Clarke M. J., 1980, MET IONS BIOL SYST, V11, P231

[9] PHASE COHERENCE AND SOLVENT SUPPRESSION IN ROTATING-FRAME CORRELATION EXPERIMENTS IN LIQUIDS [J].

ESPOSITO, G ;

GIBBONS, WA ;

BAZZO, R .

JOURNAL OF MAGNETIC RESONANCE, 1988, 80 (03) :523-527

[10] STRUCTURE OF [PLATINUM(ETHYLENEDIAMINE)(GUANOSINE)2]2+ CATION [J].

GELLERT, RW ;

BAU, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (25) :7379-7380