CHEMICAL CHARACTERIZATION OF THE PARASITOPHOROUS VACUOLE MEMBRANE ANTIGEN QF 116 FROM PLASMODIUM-FALCIPARUM

被引：27

作者：

KARA, U

MURRAY, B

PAM, C

LAHNSTEIN, J

GOULD, H

KIDSON, C

SAUL, A

机构：

[1] BIOTECHNOL AUSTRALIA,SYDNEY,AUSTRALIA

[2] COMMONWEALTH SERUM LABS,MELBOURNE,AUSTRALIA

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1990年 / 38卷 / 01期

关键词：

Blood-stage parasite; Epitope mapping; Myristylation; Parasitophorous vacuole membrane; Plasmodium falciparum; Signal peptide;

D O I：

10.1016/0166-6851(90)90200-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

On the basis of amino acid sequencing and immunological cross-reactivity, the Plasmodium falciparum parasitophorous vacuole antigens QF116 and exp-1/CRA are apparently identical. The epitope recognized by an inhibitory monoclonal antibody directed against QF116 is located proximal to the C-terminus of the protein. The QF116 protein is processed during maturation by the cleavage of a 22-amino-acid signal peptide and acylated as measured by labeling with myristic acid. © 1990.

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页码：19 / 23

页数：5

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