EFFECT OF CLONIDINE, NIMODIPINE AND DILTIAZEM ON THE INVITRO OPIOID WITHDRAWAL RESPONSE IN THE GUINEA-PIG ILEUM

被引:20
作者
ALFARO, MJ [1 ]
COLADO, MI [1 ]
LOPEZ, F [1 ]
MARTIN, MI [1 ]
机构
[1] UNIV COMPLUTENSE MADRID,FAC MED,INST FARMACOL & TOXICOL,DEPT FARMACOL,MADRID 3,SPAIN
关键词
D O I
10.1111/j.1476-5381.1990.tb14187.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. The effects of clonidine, nimodipine and diltiazem, on the in vitro withdrawal contracture induced by naloxone in the guinea-pig ileum obtained from morphine-dependent animals, were evaluated. 2. The in vitro incubation with clonidine (0.01, 0.1 and 1 μM), diltiazem (0.25, 0.5 and 1 μM) or nimodipine (0.05, 0.1 and 1 μM) reduced significantly the force of the contracture induced by naloxone in the morphine-dependent guinea-pig ileum. 3. The intraperitoneal administration of clonidine (0.3 mg kg-1), nimodipine (5 mg kg-1) or diltiazem (20 mg kg-1) reduced the contractile response induced by naloxone in the morphine-dependent guinea-pig ileum. 4. It is concluded that at least part of the effect of clonidine, nimodipine and diltiazem on withdrawal contractures is mediated via a peripheral, rather than a central site of action. Even though, the mechanism responsible for the effect of the calcium channel blockers differs from that of α2-adrenoceptor agonists, all of the drugs tested prevented the contracture induced by naloxone in morphine-dependent guinea-pig ileum.
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页码:958 / 960
页数:3
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