Lithiation of 3,5-dimethyl- and 5-trifluoromethyl-1-phenylpyrazoles with butyllithium is found to be directed to an ortho position. The ortho direction is ascribed to coordination of lithium with pyrazole 2-nitrogen or 5-trifluoromethyl group, respectively.
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[1]
Elguero J., 1984, COMPR HETEROCYCL CHE, P167, DOI DOI 10.1016/B978-008096519-2.00072-2