DIRECTED ORTHO-LITHIATION IN THE REACTIONS OF 3,5-DIMETHYL-1-PHENYLPYRAZOLE AND 5-TRIFLUOROMETHYL-1-PHENYLPYRAZOLE WITH BUTYLLITHIUM

被引:13
作者
IWATA, S [1 ]
QIAN, CP [1 ]
TANAKA, K [1 ]
机构
[1] SEIKEI UNIV, FAC ENGN, MUSASHINO, TOKYO 180, JAPAN
关键词
D O I
10.1246/cl.1992.357
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Lithiation of 3,5-dimethyl- and 5-trifluoromethyl-1-phenylpyrazoles with butyllithium is found to be directed to an ortho position. The ortho direction is ascribed to coordination of lithium with pyrazole 2-nitrogen or 5-trifluoromethyl group, respectively.
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页码:357 / 360
页数:4
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