LECTIN AFFINITY ELECTROPHORESIS OF ALPHA-FETOPROTEIN - INCREASED SPECIFICITY AND SENSITIVITY AS A MARKER OF HEPATOCELLULAR-CARCINOMA

被引：17

作者：

HIRAI, H ^{[1
]}

TAKETA, K ^{[1
]}

机构：

[1] OKAYAMA UNIV,SCH MED,DEPT PUBL HLTH,OKAYAMA 700,JAPAN

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 604卷 / 01期

关键词：

D O I：

10.1016/0021-9673(92)85532-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Alpha-Fetoprotein (AFP) is widely used as a marker of hepatocellular carcinoma (HCC) for assisting diagnosis and also for screening purposes, even though its sensitivity has been decreased slightly as a result of the earlier detection of HCC by ultrasonography. Using lectin-dependent fractionation of AFP, the diagnostic sensitivity as well as the specificity of AFP can be increased compared with measurement of total AFP. Furthermore, lectin-reactive forms of AFP, AFP-L3 and AFP-P4, have been shown to serve as preclinical markers of HCC. Accordingly, AFP is still the most reliable marker of HCC in screening and monitoring high-risk patients.

引用

页码：91 / 94

页数：4

共 9 条

[1] MICROHETEROGENEITY OF ALPHA-FETOPROTEIN IN PATIENT SERUM AS DEMONSTRATED BY LECTIN AFFINO-ELECTROPHORESIS [J].