STRIATAL SUBREGIONS ARE DIFFERENTIALLY VULNERABLE TO THE NEUROTOXIC EFFECTS OF METHAMPHETAMINE

被引：102

作者：

EISCH, AJ ^{[1
]}

GAFFNEY, M ^{[1
]}

WEIHMULLER, FB ^{[1
]}

ODELL, SJ ^{[1
]}

MARSHALL, JF ^{[1
]}

机构：

[1] UNIV CALIF IRVINE, DEPT PSYCHOBIOL, IRVINE, CA 92717 USA

来源：

BRAIN RESEARCH | 1992年 / 598卷 / 1-2期

关键词：

METHAMPHETAMINE; STRIATUM; NEUROTOXICITY; HETEROGENEITY; DOPAMINE; MAZINDOL; AUTORADIOGRAPHY; RAT;

D O I：

10.1016/0006-8993(92)90201-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Methamphetamine (m-AMPH) or saline was repeatedly administered to rats. One week later, the caudate-putamen of the m-AMPH-treated rats revealed a decrease in both [H-3]mazindol-labeled dopamine uptake sites and tissue dopamine content. Moreover, the resulting pattern of decline in these measures was regionally heterogeneous. The ventral caudate-putamen displayed the greatest decrease in both [H-3]mazindol binding and dopamine content while the neighboring nucleus accumbens and the dorsal caudate-putamen remained relatively intact. These results indicate a regional difference in the susceptibility of striatal dopaminergic terminals to the neurotoxic effects of methamphetamine.

引用

页码：321 / 326

页数：6

共 37 条

[1] ALPHA-METHYL-P-TYROSINE PRETREATMENT PARTIALLY PREVENTS METHAMPHETAMINE-INDUCED ENDOGENOUS NEUROTOXIN FORMATION
AXT, KJ
COMMINS, DL
VOSMER, G
SEIDEN, LS
[J]. BRAIN RESEARCH, 1990, 515 (1-2) : 269 - 276
[2] TOPOGRAPHICAL DOPAMINE AND SEROTONIN DISTRIBUTION AND TURNOVER IN RAT STRIATUM
BEAL, MF
MARTIN, JB
[J]. BRAIN RESEARCH, 1985, 358 (1-2) : 10 - 15
[3] THE EFFECT OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP) ON STRIATAL AND LIMBIC CATECHOLAMINE NEURONS IN WHITE AND BLACK MICE - ANTAGONISM BY MONOAMINE-OXIDASE INHIBITORS
BRADBURY, AJ
COSTALL, B
JENNER, PG
KELLY, ME
MARSDEN, CD
NAYLOR, RJ
[J]. NEUROPHARMACOLOGY, 1986, 25 (08) : 897 - 904
[4] A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
BURNS, RS
CHIUEH, CC
MARKEY, SP
EBERT, MH
JACOBOWITZ, DM
KOPIN, IJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14): : 4546 - 4550
[5] AMPHETAMINE, COCAINE, PHENCYCLIDINE AND NOMIFENSINE INCREASE EXTRACELLULAR DOPAMINE CONCENTRATIONS PREFERENTIALLY IN THE NUCLEUS ACCUMBENS OF FREELY MOVING RATS
CARBONI, E
IMPERATO, A
PEREZZANI, L
DICHIARA, G
[J]. NEUROSCIENCE, 1989, 28 (03) : 653 - 661
[6] PRIMATE MODEL OF PARKINSONISM - SELECTIVE LESION OF NIGROSTRIATAL NEURONS BY 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE PRODUCES AN EXTRAPYRAMIDAL SYNDROME IN RHESUS-MONKEYS
CHIUEH, CC
BURNS, RS
MARKEY, SP
JACOBOWITZ, DM
KOPIN, IJ
[J]. LIFE SCIENCES, 1985, 36 (03) : 213 - 218
[7] LONG-TERM CHANGES IN DOPAMINERGIC INNERVATION OF CAUDATE-NUCLEUS AFTER CONTINUOUS AMPHETAMINE ADMINISTRATION
ELLISON, G
EISON, MS
HUBERMAN, HS
DANIEL, F
[J]. SCIENCE, 1978, 201 (4352) : 276 - 278
[8] SYMPTOMATIC AND ASYMPTOMATIC 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-TREATED PRIMATES - BIOCHEMICAL-CHANGES IN STRIATAL REGIONS
ELSWORTH, JD
DEUTCH, AY
REDMOND, DE
TAYLOR, JR
SLADEK, JR
ROTH, RH
[J]. NEUROSCIENCE, 1989, 33 (02) : 323 - 331
[9] JAVITCH JA, 1985, J NEUROSCI, V5, P1513
[10] [MAZINDOL-H-3 BINDING ASSOCIATED WITH NEURONAL DOPAMINE UPTAKE SITES IN CORPUS STRIATUM MEMBRANES
JAVITCH, JA
BLAUSTEIN, RO
SNYDER, SH
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1983, 90 (04) : 461 - 462

← 1 2 3 4 →