LOCAL AND SYSTEMIC IMMUNE-RESPONSES IN MURINE HELICOBACTER-FELIS ACTIVE CHRONIC GASTRITIS

被引:104
作者
FOX, JG
BLANCO, M
MURPHY, JC
TAYLOR, NS
LEE, A
KABOK, Z
PAPPO, J
机构
[1] MIT,DIV COMPARAT MED,CAMBRIDGE,MA 02139
[2] ORAVAX INC,VACCINE DELIVERY RES,CAMBRIDGE,MA 02139
[3] SCH MICROBIOL NEW S WALES,SYDNEY,AUSTRALIA
关键词
D O I
10.1128/IAI.61.6.2309-2315.1993
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Helicobacter felis inoculated per os into germfree mice and their conventional non-germfree counterparts caused a persistent chronic gastritis of approximately 1 year in duration. Mononuclear leukocytes were the predominant inflammatory cell throughout the study, although polymorphonuclear cell infiltrates were detected as well. Immunohistochemical analyses of gastric mucosa from H. felis-infected mice revealed the presence of mucosal B220+ cells coalescing into lymphoid follicles surrounded by aggregates of Thy-1.2+ T cells; CD4+, CD5+, and alphabeta T cells predominated in organized gastric mucosal and submucosal lymphoid tissue, and CD11b+ cells occurred frequently in the mucosa. Follicular B cells comprised immunoglobulin M+ (IgM+) and IgA+ cells. Numerous IgA-producing B cells were present in the gastric glands, the lamina propria, and gastric epithelium. Infected animals developed anti-H. felis serum IgM antibody responses up to 8 weeks postinfection and significant levels of IgG anti-H. felis antibody in serum, which remained elevated throughout the 50-week course of the study.
引用
收藏
页码:2309 / 2315
页数:7
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