MORPHINE-INDUCED STRAUB TAIL RESPONSE - MEDIATED BY CENTRAL MU(2)-OPIOID RECEPTOR

被引：31

作者：

NATH, C ^{[1
]}

GUPTA, MB ^{[1
]}

PATNAIK, GK ^{[1
]}

DHAWAN, KN ^{[1
]}

机构：

[1] CENT DRUG RES INST,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 263卷 / 1-2期

关键词：

MORPHINE; STRAUB TAIL; MU(2)-OPIOID RECEPTOR;

D O I：

10.1016/0014-2999(94)90543-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The opioid receptor mechanism involved in the morphine induced straub tail response was investigated in mice. Morphine (2.5, 5, 10 and 20 mg/kg s.c.) produced a dose dependent straub tail response and analgesia (hot plate test). Naloxone (5 mg/kg s.c.) and the mu-opioid receptor antagonist beta-funaltrexamine (10 mu g i.c.v.) blocked both the straub tail response and analgesia while the mu(1)-opioid receptor selective antagonist naloxonazine (35 mg/kg s.c.) blocked only analgesia and did not affect the straub tail response. Morphine (20 mu g) administered by the i.c.v. route also produced the straub tail response as well as analgesia. Pretreatment with naloxonazine (35 mg/kg s.c.) antagonised i.c.v. administered morphine induced analgesia while the straub tail response was not affected. The results indicate that the morphine induced straub tail response is mediated by central mu(2)-opioid receptors.

引用

页码：203 / 205

页数：3

共 12 条

[1] QUANTITATIVE STUDIES OF ANTAGONISM BY NALORPHINE OF SOME OF ACTIONS OF MORPHINE-LIKE ANALGESIC DRUGS [J].