FREQUENT POLYMORPHISM IN EXON-15 OF THE ADENOMATOUS POLYPOSIS-COLI GENE

被引：9

作者：

DAVIES, SM ^{[1
]}

SNOVER, DC ^{[1
]}

机构：

[1] UNIV MINNESOTA,DEPT SURG PATHOL,MINNEAPOLIS,MN 55455

来源：

HUMAN GENETICS | 1994年 / 93卷 / 03期

关键词：

D O I：

10.1007/BF00212032

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In the course of a study of tumor suppressor gene mutation in hepatoblastoma, a frequent neutral polymorphism was identified at codon 1493 in exon 15 of the gene causing adenomatous polyposis coli (APC). As the polymorphism introduces a new BsaJ1 site, DNA amplified by the polymerase chain reaction (PCR) can be rapidly screened for this polymorphism. This polymorphism can be used in cosegregation studies for presymptomatic diagnosis of APC and family studies.

引用

页码：329 / 330

页数：2

共 4 条

[1] IDENTIFICATION AND CHARACTERIZATION OF THE FAMILIAL ADENOMATOUS POLYPOSIS-COLI GENE [J].

GRODEN, J ;

THLIVERIS, A ;

SAMOWITZ, W ;

CARLSON, M ;

GELBERT, L ;

ALBERTSEN, H ;

JOSLYN, G ;

STEVENS, J ;

SPIRIO, L ;

ROBERTSON, M ;

SARGEANT, L ;

KRAPCHO, K ;

WOLFF, E ;

BURT, R ;

HUGHES, JP ;

WARRINGTON, J ;

MCPHERSON, J ;

WASMUTH, J ;

LEPASLIER, D ;

ABDERRAHIM, H ;

COHEN, D ;

LEPPERT, M ;

WHITE, R .

CELL, 1991, 66 (03) :589-600

[2] MUTATIONS OF CHROMOSOME-5Q21 GENES IN FAP AND COLORECTAL-CANCER PATIENTS [J].

NISHISHO, I ;

NAKAMURA, Y ;

MIYOSHI, Y ;

MIKI, Y ;

ANDO, H ;

HORII, A ;

KOYAMA, K ;

UTSUNOMIYA, J ;

BABA, S ;

HEDGE, P ;

MARKHAM, A ;

KRUSH, AJ ;

PETERSEN, G ;

HAMILTON, SR ;

NILBERT, MC ;

LEVY, DB ;

BRYAN, TM ;

PREISINGER, AC ;

SMITH, KJ ;

SU, LK ;

KINZLER, KW ;

VOGELSTEIN, B .

SCIENCE, 1991, 253 (5020) :665-669

[3] DNA SEQUENCING WITH CHAIN-TERMINATING INHIBITORS [J].

SANGER, F ;

NICKLEN, S ;

COULSON, AR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (12) :5463-5467

[4] THE EXPECTED EQUILIBRIUM OF THE CPG DINUCLEOTIDE IN VERTEBRATE GENOMES UNDER A MUTATION MODEL [J].

SVED, J ;

BIRD, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (12) :4692-4696

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