QUANTITATIVE TRAIT LOCI MAPPING OF 3 LOCI CONTROLLING MORPHINE PREFERENCE USING INBRED MOUSE STRAINS

被引：152

作者：

BERRETTINI, WH ^{[1
]}

FERRARO, TN ^{[1
]}

ALEXANDER, RC ^{[1
]}

BUCHBERG, AM ^{[1
]}

VOGEL, WH ^{[1
]}

机构：

[1] THOMAS JEFFERSON UNIV,JEFFERSON CANC INST,DEPT PHARMACOL,PHILADELPHIA,PA 19107

来源：

NATURE GENETICS | 1994年 / 7卷 / 01期

关键词：

D O I：

10.1038/ng0594-54

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Quantitative trait loci mapping was used to identify the chromosomal location of genes which contribute to oral morphine preference (in a two-bottle choice paradigm) of C57BL/6J mice, compared to DBA/2J mice. An F-2 intercross of these two strains (606 mice) was phenotyped for morphine preference and those mice demonstrating extreme values for morphine consumption (the highest and lowest 7.7%) were genotyped for 157 murine microsatellite polymorphisms. Maximum likelihood methods revealed three loci on murine chromosomes 1, 6 and 10 which are responsible for nearly 85% of the genetic variance observed between the two parental strains.

引用

页码：54 / 58

页数：5

共 41 条

[1] ALEXANDER RC, 1993, PSYCHIAT GENET, V3, P33
[2] EMPIRICAL ESTIMATES OF BONFERRONI CORRECTIONS FOR USE IN CHROMOSOME MAPPING STUDIES WITH THE BXD RECOMBINANT INBRED STRAINS
BELKNAP, JK
[J]. BEHAVIOR GENETICS, 1992, 22 (06) : 677 - 684
[3] SINGLE-LOCUS CONTROL OF SACCHARIN INTAKE IN BXD TY RECOMBINANT INBRED (RI) MICE - SOME METHODOLOGICAL IMPLICATIONS FOR RI STRAIN ANALYSIS
BELKNAP, JK
CRABBE, JC
PLOMIN, R
MCCLEARN, GE
SAMPSON, KE
OTOOLE, LA
GORAMASLAK, G
[J]. BEHAVIOR GENETICS, 1992, 22 (01) : 81 - 100
[4] GENETIC DISSOCIATION OF MULTIPLE MORPHINE EFFECTS AMONG C57BL/6J, DBA/2J AND C3H-HEJ INBRED MOUSE STRAINS
BELKNAP, JK
NOORDEWIER, B
LAME, M
[J]. PHYSIOLOGY & BEHAVIOR, 1989, 46 (01) : 69 - 74
[5] PHYSICAL-DEPENDENCE INDUCED BY THE VOLUNTARY CONSUMPTION OF MORPHINE IN INBRED MICE
BELKNAP, JK
[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1990, 35 (02) : 311 - 315
[6] VOLUNTARY CONSUMPTION OF MORPHINE IN 15 INBRED MOUSE STRAINS
BELKNAP, JK
CRABBE, JC
RIGGAN, J
OTOOLE, LA
[J]. PSYCHOPHARMACOLOGY, 1993, 112 (2-3) : 352 - 358
[7] BERRETTINI WH, 1991, PSYCHIAT GENET, V2, P191
[8] BERRETTINI WH, IN PRESS PSYCHIAT GE
[9] BRASE DA, 1977, J PHARMACOL EXP THER, V201, P368
[10] CADORET RJ, 1986, ARCH GEN PSYCHIAT, V43, P1131

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