GDNF - EXISTENCE OF A 2ND TRANSCRIPT IN THE BRAIN

被引：21

作者：

CRISTINA, N ^{[1
]}

CHATELLARDCAUSSE, C ^{[1
]}

MANIER, M ^{[1
]}

FEUERSTEIN, C ^{[1
]}

机构：

[1] CHU GRENOBLE,UNIV GRENOBLE 1,F-38043 GRENOBLE 9,FRANCE

来源：

MOLECULAR BRAIN RESEARCH | 1995年 / 32卷 / 02期

关键词：

GDNF; NEUROTROPHIC FACTOR; RT-PCR; MESSENGER-RNA SPLICING; PRECURSOR PROTEIN; RAT BRAIN;

D O I：

10.1016/0169-328X(95)00103-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The detection of the glial cell-line derived neurotrophic factor (GDNF) mRNA by RT-PCR in dissociated cell culture of rat embryonic or post-natal brain allowed the amplification of a doublet. The major band corresponded to the expected size and the minor one to a shorter product. We cloned and sequenced the latter product, and thus identified a mRNA potentially encoding for an isoform of the initially described precursor protein involved in GDNF synthesis.

引用

页码：354 / 357

页数：4

共 20 条

[1] INTRASTRIATAL TRANSPLANTS OF EMBRYONIC DOPAMINERGIC-NEURONS COUNTERACT THE INCREASE OF STRIATAL ENKEPHALIN IMMUNOSTAINING BUT NOT SEROTONINERGIC SPROUTING ELICITED BY A NEONATAL LESION OF THE NIGROSTRIATAL DOPAMINERGIC PATHWAY [J].

ABROUS, DN ;

MANIER, M ;

MENNICKEN, F ;

FEUERSTEIN, C ;

LEMOAL, M ;

HERMAN, JP .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1993, 5 (02) :128-136

[2] MESENCEPHALIC DOPAMINERGIC-NEURONS PROTECTED BY GDNF FROM AXOTOMY-INDUCED DEGENERATION IN THE ADULT BRAIN [J].

BECK, KD ;

VALVERDE, J ;

ALEXI, T ;

POULSEN, K ;

MOFFAT, B ;

VANDLEN, RA ;

ROSENTHAL, A ;

HEFTI, F .

NATURE, 1995, 373 (6512) :339-341

[3]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[4] CONDITIONED MEDIA DERIVED FROM GLIAL-CELL LINES PROMOTE SURVIVAL AND DIFFERENTIATION OF DOPAMINERGIC-NEURONS INVITRO - ROLE OF MESENCEPHALIC GLIA [J].

ENGELE, J ;

SCHUBERT, D ;

BOHN, MC .

JOURNAL OF NEUROSCIENCE RESEARCH, 1991, 30 (02) :359-371

[5] REQUIREMENT FOR ACTIVIN-A AND TRANSFORMING GROWTH FACTOR-BETA-1 PRO-REGIONS IN HOMODIMER ASSEMBLY [J].

GRAY, AM ;

MASON, AJ .

SCIENCE, 1990, 247 (4948) :1328-1330

[6] GDNF - A POTENT SURVIVAL FACTOR FOR MOTONEURONS PRESENT IN PERIPHERAL-NERVE AND MUSCLE [J].

HENDERSON, CE ;

PHILLIPS, HS ;

POLLOCK, RA ;

DAVIES, AM ;

LEMEULLE, C ;

ARMANINI, M ;

SIMPSON, LC ;

MOFFET, B ;

VANDLEN, RA ;

KOLIATSOS, VE ;

ROSENTHAL, A .

SCIENCE, 1994, 266 (5187) :1062-1064

[7] NEURONS OF THE HIPPOCAMPAL-FORMATION EXPRESS GLIAL-CELL LINE-DERIVED NEUROTROPHIC FACTOR MESSENGER-RNA IN RESPONSE TO KAINATE-INDUCED EXCITATION [J].

HUMPEL, C ;

HOFFER, B ;

STROMBERG, I ;

BEKTESH, S ;

COLLINS, F ;

OLSON, L .

NEUROSCIENCE, 1994, 59 (04) :791-795

[8] TGF-BETA-1 BINDING-PROTEIN - A COMPONENT OF THE LARGE LATENT COMPLEX OF TGF-BETA-1 WITH MULTIPLE REPEAT SEQUENCES [J].

KANZAKI, T ;

OLOFSSON, A ;

MOREN, A ;

WERNSTEDT, C ;

HELLMAN, U ;

MIYAZONO, K ;

CLAESSONWELSH, L ;

HELDIN, CH .

CELL, 1990, 61 (06) :1051-1061

[9]

KAPLAN JC, 1990, BIOL MOL MED, P95

[10] TRANSFORMING GROWTH-FACTOR-BETA PROMOTES SURVIVAL OF MIDBRAIN DOPAMINERGIC-NEURONS AND PROTECTS THEM AGAINST N-METHYL-4-PHENYLPYRIDINIUM ION TOXICITY [J].

KRIEGLSTEIN, K ;

UNSICKER, K .

NEUROSCIENCE, 1994, 63 (04) :1189-1196

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