NITRIC-OXIDE SYNTHASE INHIBITION DECREASES PONTINE ACETYLCHOLINE-RELEASE

被引：46

作者：

LEONARD, TO ^{[1
]}

LYDIC, R ^{[1
]}

机构：

[1] PENN STATE UNIV,COLL MED,DEPT ANESTHESIA,HERSHEY,PA 17033

来源：

NEUROREPORT | 1995年 / 6卷 / 11期

关键词：

NITRIC OXIDE; ACETYLCHOLINE; REM SLEEP; PENS; MICRODIALYSIS;

D O I：

10.1097/00001756-199507310-00015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THIS Study tested the hypothesis that inhibition of nitric oxide synthase (NOS) in the medial pontine reticular formation (mPRF) would cause decreased acetylcholine (ACh) release. Microdialysis of cat mPRF permitted measurement of ACh during states of wakefulness, non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep. ACh release during microdialysis with Ringers (control) was compared to ACh release during microdialysis with 10 mM N-G-nitro-L-arginine (NLA). The NOS inhibitor NLA caused a significant reduction in ACh released from the mPRF during wakefulness, NREM sleep, and REM sleep. This reduction in mPRF ACh release elicited by NLA suggests that nitric oxide (NO) contributes to cholinergic neurotransmission in the pontine reticular formation.

引用

页码：1525 / 1529

页数：5

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