ELECTROENCEPHALOGRAPHIC EFFECTS OF ANTIEPILEPTIC DRUG-THERAPY

被引：3

作者：

DRAKE, ME ^{[1
]}

HUBER, SJ ^{[1
]}

PAKALNIS, A ^{[1
]}

DENIO, L ^{[1
]}

机构：

[1] OHIO STATE UNIV,COLL MED,DEPT NEUROL,COLUMBUS,OH 43210

来源：

JOURNAL OF EPILEPSY | 1990年 / 3卷 / 02期

关键词：

Antiepileptic drugs; EEG; Epilepsy; Spectral analysis;

D O I：

10.1016/0896-6974(90)90154-Q

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated the effects of therapeutic levels of antiepileptic drug (AED) monotherapy on computed measures of EEG frequency in seizure patients with normal interictal EEGs. Fourteen patients were taking phenobarbital, 14 were taking phenytoin, 13 were taking carbamazepine, and 12 were taking valproate. One-minute EEG spectra were recorded from Oz-A1 + A2. We measured the predominant alpha band frequency (modal alpha frequency-MAF), fastest alpha band frequency (maximal alpha frequency-MxAF), and highest prominent frequency between 13 and 30 Hz (spectral edge frequency-SEF). Patients taking phenobarbital or valproate had significantly lower MAF than those taking carbamazepine or phenytoin. MxAF did not differ significantly among the four patient groups. SEF was significantly lower in patients on valproate and carbamazepine than in those on other AEDs. Phenobarbital slowed background activity in the interictal EEG, whereas phenytoin and carbamazepine at therapeutic levels did not have such an effect. Valproate produced alpha and beta frequency decrease in the otherwise normal interictal EEG. © 1990.

引用

页码：75 / 79

页数：5

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