ASYMMETRIC REACTIONS OF ENAMINES WITH METHYL (E)-4-OXO-4-(2-OXO-1,3-OXAZOLIDIN-3-YL)-2-BUTENOATE BY THE USE OF A CHIRAL TITANIUM REAGENT

被引：21

作者：

HAYASHI, Y ^{[1
]}

OTAKA, K ^{[1
]}

SAITO, N ^{[1
]}

NARASAKA, K ^{[1
]}

机构：

[1] UNIV TOKYO, FAC SCI, DEPT CHEM, BUNKYO KU, TOKYO 113, JAPAN

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1991年 / 64卷 / 07期

关键词：

D O I：

10.1246/bcsj.64.2122

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Asymmetric Michael and [2+2] cycloaddition reactions between enamines and methyl (E)-4-oxo-4-(2-oxo-1,3-oxazolidin-3-yl)-2-butenoate proceed with a chiral titanium reagent generated in situ from dichlorodiisopropoxytitanium and a tartrate-derived chiral 1,4-diol. In the presence of excess amounts of the chiral titanium reagent, good to moderate enantioselectivity is attained. The reactions are also well catalyzed even with a catalytic amount of the titanium reagent.

引用

页码：2122 / 2127

页数：6

共 38 条

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