TRANSITION-METAL DIRECTED SYNTHESIS OF MORACIN-M, A PHYTOALEXIN OF MORUS-ALBA LINN

被引：40

作者：

MANN, IS

WIDDOWSON, DA

CLOUGH, JM

机构：

[1] UNIV LONDON IMPERIAL COLL SCI & TECHNOL,DEPT CHEM,LONDON SW7 2AY,ENGLAND

[2] ICI AGROCHEM,JEALOTTS HILL RES STN,BRACKNELL RG12 6EY,BERKS,ENGLAND

来源：

TETRAHEDRON | 1991年 / 47卷 / 37期

关键词：

MORACIN SYNTHESIS; ARENETRICARBONYLCHROMIUM(0) COMPLEXES; REMOTE LITHIATION; PALLADIUM CATALYZED CROSS COUPLING;

D O I：

10.1016/S0040-4020(01)81951-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-(5-Resorcinyl)benzofurans have been synthesised by the palladium catalysed cross coupling of 2-trimethylstannyl- or 2-bromozinc benzofurans with the appropriately functionalised 5-iodoresorcinols. These were synthesised by the tri-isopropylsilyloxy directed remote (C-5) lithiation/iodination of the O,O-di(tri-isopropylsily)resorcinoltricarbonylchromium(0) complex. The method was applied to the synthesis of moracin M a phytoalexin of Morus alba Linn.

引用

页码：7981 / 7990

页数：10

共 15 条

[1] UNSYMMETRICAL HETEROBIARYL SYNTHESIS - A HIGHLY EFFICIENT PALLADIUM-CATALYZED CROSS-COUPLING REACTION OF HETEROARYL TRIALKYLSTANNANES WITH ARYL HALIDES [J].