COMPARATIVE MAPPING OF ZFY IN THE HOMINOID APES

被引:10
作者
MULLER, G [1 ]
SCHEMPP, W [1 ]
机构
[1] UNIV FREIBURG,INST HUMANGENET & ANTHROPOL,BREISACHER STR 33,W-7800 FREIBURG,GERMANY
关键词
D O I
10.1007/BF00204930
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Within our project of comparative mapping of candidate genes for sex-determination/testis differentiation, we used a cloned probe from the human ZFY locus for comparative hybridization studies in hominoids. As in the human, the ZFY probe detects X- and Y-specific restriction fragments in the chimpanzee, the gorilla, the orangutan, and the gibbon. Furthermore, the X-specific hybridization site in the great apes resides in Xp21.3, the same locus defining ZFX in the human. The Y-specific locus of ZFY maps closely to the early replicating pseudoautosomal segment in the telomeric or subtelomeric position of the Y chromosomes of the great apes, again as found in the human. Thus, despite cytogenetically visible structural alterations within the euchromatic parts of the Y chromosomes of the human species and the great apes, a segment of the Y chromosome defined by the pseudoautosomal region and ZFY seems to be more strongly conserved than the rest of the Y chromosome.
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页码:59 / 63
页数:5
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