Gene disruption in mammals

被引：10

作者：

Rossant, Janet ^{[1
,2
]}

机构：

[1] Univ Toronto, Samuel Lunenfeld Res Inst, Mt Sinai Hosp, 600 Univ Ave, Toronto, ON M5G 1X5, Canada

[2] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M5G 1X5, Canada

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1991年 / 1卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(05)80076-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the past year, the first phenotypes have been reported for mutations targeted to developmentally relevant genes by homologous recombination in embryonic stem cells. The results indicate that the genetic circuitry of mammalian development is complex and will require more sophisticated analysis than simple gene disruption. Improvements in the technology of targeted mutagenesis may assist in such analysis.

引用

页码：236 / 240

页数：5

共 38 条

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