EFFECTS OF SHORT-TERM GNRH AGONIST - HUMAN MENOPAUSAL GONADOTROPIN STIMULATION IN PATIENTS PRETREATED WITH PROGESTOGEN

被引：12

作者：

HUGUES, JN

ATTALAH, M

HERVE, F

MARTINPONT, B

KOTTLER, ML

SANTARELLI, J

机构：

[1] Unité de Procréation Médicalement Assistée, Hôpital Jean Verdier, Bondy 93143

[2] Laboratoire de Biochimie Médicale, Université Paris V

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 08期

关键词：

IVF ET; OVARIAN STIMULATION; PROGESTOGEN PRETREATMENT; SHORT PROTOCOL;

D O I：

10.1093/oxfordjournals.humrep.a137796

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The recent use of gonadotrophin-releasing hormone agonist in a short-term regimen has allowed the effectiveness of human menopausal gonadotrophin (HMG) stimulation to be markedly improved. It seems to be related to the flare-up effect of the agonist in the early follicular phase of the cycle. However, individual hormonal responses to the agonist are quite variable and four patterns of oestradiol secretion have been described. The present study indicates that in women pre-treated with progestogen, only two patterns of serum oestradiol are observed in the flare-up period, with a significant increase in 57% of patients. Significant correlations are observed between oestradiol values and the endogenous gonadotrophin surge (positively with luteinizing hormone, r = 0.38; P < 0.05 and negatively with follicle stimulating hormone, r = 0.48; P < 0.005). Furthermore, there was a significant relationship between the hormonal flare-up and the ovarian parameters following HMG stimulation. In conclusion, in progestogen-pre-treated women, the serum oestradiol level during the flare-up period is a reliable index to predict subsequent effectiveness of ovarian stimulation with HMG.

引用

页码：1079 / 1084

页数：6

共 27 条

[1]

Abraham G.E., Radioimmunoassay of steroids in biological materials. Acta Endocrinol, (Copenh) Suppl, 18, 75, pp. 7-42, (1974)

[2]

Barriere, Lopes P.P., Boiffard J.P., Pousset C., Quentin M., Sagot P., L'Hermine, Lerat A.M.F., Charbonnel B., Use of GnRH analogues in ovulation induction for in vitro fertilization: Benefit of a short administration regimen. J, Vitro Fertil. Embryo Transfer, 4, pp. 64-65, (1987)

[3]

Benadiva C.A., Ben Rafael Z., An increased initial follicle-stimulating hormone/luteinizing hormone ratio does not affect ovarian responses and the outcomes of in vitro fertilization. Fertil, Steril, 50, pp. 777-781, (1988)

[4]

Benadiva C.A., Blasco L., Tureck R., Mastroianni L., Flick-Inger G.L., Comparison of Different Regimens of a Gonadotropin-Releasing Hormone Analog during Ovarian Stimulation for in Vitro Fertilization. Fertil. Steril, 53, pp. 479-485, (1990)

[5]

Brzyski R.G., Muasher S.J., Froesch K., Simonetti S., Jones G.S., Rosenwaks Z., Follicular atresia associated with concurrent initiation of gonadotropin-releasing hormone agonist and follicle- stimulating hormone for oocyte recruitment. Fertil, Steril, 50, pp. 917-921, (1988)

[6]

Cameron I.T., O'Shea F.C., Rolland J.M., Hughes E., De Kretser G.D.M., Healy D.L., Occult Ovarian Failure: A Syndrome of Infertility, Regular Menses and Elevated Follicle-Stimulating Hormone Concentrations. J. Clin. Endocrinol. Metab, 67, pp. 1190-1194, (1988)

[7]

Check J.H., Nowroozi R., Chase J.S., Comparison of Short versus Long-Term Leuprolide Acetate -Human Menopausalgonadotrophin Hyperstimulation in In-Vitro Fertilization Patients. Hum. Reprod, 7, pp. 31-34, (1992)

[8]

Fenichel Grimaldi P.M., Olivero J.F., Donzeau M., Gillet J.Y., Harter M., Predictive Value of Hormonal Profiles before Stimulation for in Vitro Fertilization. Fertil. Steril, 51, pp. 845-849, (1989)

[9]

Fleming R., Coutts J., Induction of multiple follicular growth in normally menstruating women with endogenous gonadotrophin suppression. Fertil, Steril, 45, pp. 226-230, (1986)

[10]

Forman R.G., Demouzon J., Feinstein M.C., Testart J., Frydman R., Studies on the Influence of Gonadotrophin Levels in the Early Follicular Phase on the Ovarian Response to Stimulation. Hum. Reprod, 6, pp. 113-117, (1991)

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