HOW DO T-CELL RECEPTORS, MHC MOLECULES AND SUPERANTIGENS GET TOGETHER

被引：84

作者：

WOODLAND, DL ^{[1
]}

BLACKMAN, MA ^{[1
]}

机构：

[1] UNIV TENNESSEE CTR HLTH SCI, DEPT PATHOL, MEMPHIS, TN 38163 USA

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 05期

关键词：

D O I：

10.1016/0167-5699(93)90164-G

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The current model of superantigen activity assumes that the superantigen simultaneously binds to both the MHC molecule on the presenting cell and the V(beta) element of the TCR, resulting in crosslinking of both molecules and subsequent activation of the T cell. Here, David Woodland and Marcia Blackman discuss the concept that there is an additional interaction between the TCR and MHC molecule during superantigen engagement and the significant impact this has on superantigen specificity and function.

引用

页码：208 / 212

页数：5

共 41 条

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