DIFFERENTIAL-EFFECTS OF CYCLOSPORINE AND ETRETINATE ON SERUM CYTOKINE LEVELS IN PATIENTS WITH PSORIASIS

被引：20

作者：

SHIOHARA, T ^{[1
]}

IMANISHI, K ^{[1
]}

SAGAWA, Y ^{[1
]}

NAGASHIMA, M ^{[1
]}

机构：

[1] TOKYO WOMENS MED COLL,DEPT MICROBIOL,TOKYO 162,JAPAN

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1992年 / 27卷 / 04期

关键词：

D O I：

10.1016/0190-9622(92)70224-4

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: The in vivo effects of cyclosporine and etretinate on the immune system are still unclear. Objective: Our purpose was to determine the effects of these drugs on in vivo production of various cytokines. Methods: Serum cytokine levels were measured sequentially by radioimmunoassay in psoriasis patients treated with either cyclosporine or etretinate. Results: Interferon-gamma levels were initially elevated and rapidly returned to baseline levels before clinical improvement in both treatment groups. A transient increase before the relapse was also observed in some patients. Etretinate treatment resulted in a substantial decrease in tumor necrosis factor-alpha levels, whereas an unpredictable increase was found during the late phase of cyclosporine treatment. Conclusion: The in vivo effects of the antipsoriatic drugs on cytokine production are different from those demonstrated in vitro. Measurement of serum cytokine levels is useful for monitoring patients with psoriasis.

引用

页码：568 / 574

页数：7

共 27 条

[1] THE EFFECTS OF CYCLOSPORINE-A ON LYMPHOCYTE-T AND DENDRITIC CELL SUBPOPULATIONS IN PSORIASIS [J].