NEUROENDOCRINE PHENOTYPE DIFFERENTIATION IN A HAMSTER LUNG EPITHELIAL-CELL LINE UNDER LOW-OXYGEN PRESSURE OR AFTER TRANSFORMATION BY DIETHYLNITROSAMINE

被引：11

作者：

EMURA, M ^{[1
]}

OCHIAI, A ^{[1
]}

GOBERTBOHLEN, A ^{[1
]}

PANNING, B ^{[1
]}

DUNGWORTH, DL ^{[1
]}

机构：

[1] HANNOVER MED SCH,ANASTHESIOL ABT,D-30625 HANNOVER,GERMANY

来源：

TOXICOLOGY LETTERS | 1994年 / 72卷 / 1-3期

关键词：

NEUROENDOCRINE PHENOTYPE; DIFFERENTIATION; LUNG EPITHELIAL STEM CELL; HYPOXIA; DIETHYLNITROSAMINE;

D O I：

10.1016/0378-4274(94)90010-8

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Oxygen pressure as low as 5% in the gas phase or 87 mmHg in the liquid phase induced various neuroendocrine cell (NEC) phenotypes in more than 80% of cells of a cloned fetal Syrian hamster lung epithelial cell line (M3E3/C3). Further, cells from a number of colonies transformed in an anchorage-independent manner by diethylnitrosamine (DEN) demonstrated a NEC phenotype. Since the cell line used is of a pluripotent stem cell type, both hypoxia and DEN appear to possess a potency for NEC phenotype induction.

引用

页码：59 / 64

页数：6

共 17 条

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