IMMEDIATE ZIDOVUDINE TREATMENT PROTECTS SIMIAN IMMUNODEFICIENCY VIRUS-INFECTED NEWBORN MACAQUES AGAINST RAPID ONSET OF AIDS

被引：69

作者：

VANROMPAY, KKA ^{[1
]}

OTSYULA, MG ^{[1
]}

MARTHAS, ML ^{[1
]}

MILLER, CJ ^{[1
]}

MCCHESNEY, MB ^{[1
]}

PEDERSEN, NC ^{[1
]}

机构：

[1] UNIV CALIF DAVIS,SCH VET MED,DEPT MED & EPIDEMIOL,DAVIS,CA 95616

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 01期

关键词：

D O I：

10.1128/AAC.39.1.125

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is a practical animal model of pediatric AIDS. Intravenous inoculation of rhesus newborns with uncloned SIVmax resulted in a high virus load, no antiviral immune responses, severe immunodeficiency, and a high mortality rate within 3 months. In contrast, immediate oral zidovudine (AZT) treatment of SIV-inoculated rhesus newborns either prevented infection or resulted in reduced virus load, enhanced antiviral immune responses, a low frequency of AZT-resistant virus isolates, and delayed disease progression with negligible toxicity. These results suggest that early chronic AZT treatment of human immunodeficiency virus-exposed newborns may have benefits that outweigh its potential side effects.

引用

页码：125 / 131

页数：7

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