NITRIC-OXIDE AND ENDOTHELIN IN PATHOPHYSIOLOGICAL SETTINGS

被引：42

作者：

HUNLEY, TE ^{[1
]}

IWASAKI, S ^{[1
]}

HOMMA, T ^{[1
]}

KON, V ^{[1
]}

机构：

[1] VANDERBILT UNIV,SCH MED,DEPT PEDIAT,DIV NEPHROL,NASHVILLE,TN 37232

来源：

PEDIATRIC NEPHROLOGY | 1995年 / 9卷 / 02期

关键词：

ENDOTHELIN; ENDOTHELIN RECEPTORS; NITRIC OXIDE; ENDOTHELIUM;

D O I：

10.1007/BF00860758

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The role of the endothelium is now known to encompass the generation of many potent cytokines which impact endothelial cells, adjacent tissue such as smooth muscle cells, and distant sites in an autocrine, paracrine, and endocrine manner, respectively. This review addresses two of these cytokines, nitric oxide and endothelin, and describes how each effects the functions of endothelial cells, including regulation of platelet aggregation and coagulation, regulation of vasomotor tone, modulation of inflammation, and the regulation of cellular proliferation. The emphasis is on the increasingly recognized importance of the autocrine and paracrine mechanisms by which nitric oxide and endothelin act. In particular, autoinduction of endothelin is proposed as a central mechanism underlying endothelin's renowned effects. Additionally, specific nitric oxide/endothelin interactions are discussed by which each cytokine modulates the production and actions of the other. The net effect observed in a variety of physiological and pathophysiological settings, therefore, reflects a balance of these opposing functions.

引用

页码：235 / 244

页数：10

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