STRUCTURE OF CLEOMEOLIDE, A NOVEL DITERPENE LACTONE FROM CLEOME-ICOSANDRA LINN

被引:25
作者
MAHATO, SB
PAL, BC
KAWASAKI, T
MIYAHARA, K
TANAKA, O
YAMASAKI, K
机构
[1] KYUSHU UNIV, FAC PHARMACEUT SCI, FUKUOKA 812, JAPAN
[2] HIROSHIMA UNIV, SCH MED, INST PHARMACEUT SCI, HIROSHIMA 734, JAPAN
关键词
D O I
10.1021/ja00510a048
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The structure and stereochemistry of cleomeolide (1), a novel diterpene lactone isolated from C. icosandra Linn. (Syn. C. viscosa Linn.), were determined by X-ray analysis and NMR and CD [circular dichroism] spectra. The compound, C20H30O3, is monoclinic, with space group P21 and unit cell dimensions of a = 10.303 (4) .ANG., b = 12.436 (4) .ANG., c = 7.341 (3) .ANG., .beta. = 110.02 (3).degree., V = 883.70 .ANG.3 and Z = 2. The crystal structure was solved by the direct method and refined by the routine least-squares method including anisotropic (for nonhydrogen atoms) and isotropic (for hydrogen atoms) thermal parameters to a final R value of 0.052. The absolute configuration was determined from the CD curve of the ketone of 1. Cleomeolide possesses a 12-membered carbocyclic ring fused to a cyclohexane ring. It also contains a 7-membered .alpha.,.beta.-unsaturated lactone ring.
引用
收藏
页码:4720 / 4723
页数:4
相关论文
共 14 条