THE USE OF LONG-ACTING GONADOTROPIN-RELEASING-HORMONE AGONIST (GNRH-A - DECAPEPTYL) AND GONADOTROPINS VERSUS SHORT-ACTING GNRH-A (BUSERELIN) AND GONADOTROPINS BEFORE AND DURING OVARIAN STIMULATION FOR INVITRO FERTILIZATION (IVF)

被引：28

作者：

GONEN, Y

DIRNFELD, M

GOLDMAN, S

KOIFMAN, M

ABRAMOVICI, H

机构：

[1] Department of Obstetrics and Gynecology, IVF Unit, Carmel Hospital, Haifa, 34362

来源：

JOURNAL OF IN VITRO FERTILIZATION AND EMBRYO TRANSFER | 1991年 / 8卷 / 05期

关键词：

INVITRO FERTILIZATION; STIMULATION PROTOCOL; SHORT-VERSUS LONG-ACTING GONADOTROPIN-RELEASING HORMONE AGONIST;

D O I：

10.1007/BF01139780

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The efficiency of two ovarian stimulation protocols using different gonadotropin-releasing hormone agonists (GnRH-a) for in vitro fertilization (IVF) was examined and compared with human menopausal gonadotropin (hMG)-only stimulation. Fifty-four patients who had 57 aspiration cycles were treated with protocol 1, which consisted of long-acting GnRH-a D-Trp6 (Decapeptyl Depot) and hMG. Protocol 2 entailed intranasal administration of short-acting GnRH-a (Buserelin) and human menopausal gonadotropin (hMG) in 66 women who underwent 70 aspiration cycles. Fifty-five patients who had 59 ovum pickups (OPU) treated with hMG only served as a control. No differences were observed in cycle parameters and hormonal concentrations among the three groups. The total clinical pregnancy rates per OPU for patients receiving protocols 1 and 2 were 12.3 and 27.1%, respectively (P < 0.05). The pregnancy loss was significantly lower in protocol 2 than in protocol 1 (26.3 versus 71.4%; P < 0.05). Our data show superiority of short-acting GnRH-a over the long-acting agents in achievement of pregnancy and its outcome, though neither was significantly different from the hMG-only protocol.

引用

页码：254 / 259

页数：6

共 31 条

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