INTERACTIONS BETWEEN ARACHIDONIC AND EICOSAPENTAENOIC ACIDS DURING THEIR DIOXYGENASE-DEPENDENT PEROXIDATION

被引：9

作者：

LAGARDE, M ^{[1
]}

VERICEL, E ^{[1
]}

CROSET, M ^{[1
]}

CALZADA, C ^{[1
]}

BORDET, JC ^{[1
]}

GUICHARDANT, M ^{[1
]}

机构：

[1] FAC ALEXIS CARREL,HEMOBIOL LAB,LYON,FRANCE

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 1993年 / 48卷 / 01期

关键词：

D O I：

10.1016/0952-3278(93)90005-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Eicosapentaenoic acid (EPA), a major polyunsaturated fatty acid of fish has been widely proposed as a potential nutrient for decreasing platelet-endothelial cell interactions and the subsequent atherogenesis and thrombogenesis. This is mainly based upon the decrease of arachidonic acid (AA) oxygenation into bioactive molecules like thromboxane A2. In addition, EPA may be oxygenated into its own active derivatives via cell dioxygenases. We report evidence for the requirement of specific peroxides, adequately provided by AA, to allow EPA to be oxygenated into its bioactive products like prostaglandin I3, a prostacyclin mimetic. On the other hand, we present some data that argue for a decreased basal AA dioxygenation (specific peroxidation) by small concentrations of EPA. The interactions between AA and EPA are then dual, EPA being able to counteract AA oxygenation whereas EPA requires AA to be efficiently oxygenated.

引用

页码：23 / 25

页数：3

共 23 条

[1] ARACHIDONIC-ACID STRONGLY STIMULATES PROSTAGLANDIN-I3 (PGI3) PRODUCTION FROM EICOSAPENTAENOIC ACID IN HUMAN-ENDOTHELIAL CELLS [J].