EVALUATION OF FREE-RADICAL PRODUCTION IN AN ISCHEMIA-REPERFUSION MODEL IN THE RABBIT USING A TOURNIQUET

被引：12

作者：

CHOPINEAU, J

SOMMIER, MF

SAUTOU, V

机构：

[1] Laboratoire de Pharmacie Clinique Et Biotechnique, Faculté de Pharmacie, Clermont-Ferrand, 63003

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1994年 / 46卷 / 06期

关键词：

D O I：

10.1111/j.2042-7158.1994.tb03842.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Use of a tourniquet on a limb to stem blood flow is frequent in surgery. However, this results in an ischaemia-reperfusion effect that causes damage through the production of free radicals. The aim of this work was to evaluate this production of free radicals in an ischaemia-reperfusion model in the rabbit after placement of a tourniquet. Plasma lipoperoxides were measured by high-performance liquid chromatography using the malondialdehyde assay method. We found significant (P<0.01) production of free radicals 1 min after release of the tourniquet compared with controls; no variation in levels of free radicals was observed during the ischaemia phase.

引用

页码：519 / 520

页数：2

共 6 条

[1] LIPID-PEROXIDATION - A COMMON PATHOGENETIC MECHANISM [J].