PHOSPHOTYROSINE PHOSPHATASES WITH SH2 DOMAINS - REGULATORS OF SIGNAL-TRANSDUCTION

被引：176

作者：

FENG, GS

PAWSON, T

机构：

[1] G-S. Feng and T. Pawson are in the Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto

来源：

TRENDS IN GENETICS | 1994年 / 10卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0168-9525(94)90149-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Among the rapidly growing family of protein tyrosine phosphatases (PTPs), a subfamily of cytoplasmic PTPs that contain SH2 domains has been identified is both mammals and Drosophila. These PTPs each contain two tandem SH2 domains at their amino-terminus, and a single phosphatase domain. The SH2-containing PTPs appear to be downstream targets of growth factor receptor tyrosine kinases, and have been shown genetically to be required for normal development in Drosophila and in the mouse. Accumulating biochemical and genetic data therefore suggest that SH2-containing PTPs might have a physiological role in intracellular signal transduction.

引用

页码：54 / 58

页数：5

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