CONCOMITANT EXPRESSION OF HEPATOCYTE GROWTH-FACTOR (HGF), HGF ACTIVATOR AND C-MET GENES IN HUMAN GLIOMA-CELLS IN-VITRO

被引：66

作者：

MORIYAMA, T

KATAOKA, H

TSUBOUCHI, H

KOONO, M

机构：

[1] MIYAZAKI MED COLL,DEPT PATHOL 2,MIYAZAKI 88916,JAPAN

[2] MIYAZAKI MED COLL,DEPT INTERNAL MED 2,MIYAZAKI 88916,JAPAN

来源：

FEBS LETTERS | 1995年 / 372卷 / 01期

关键词：

HEPATOCYTE GROWTH FACTOR; HEPATOCYTE GROWTH FACTOR ACTIVATOR; C-MET; GLIOMA;

D O I：

10.1016/0014-5793(95)00949-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three nem cell lines of human glioblastoma have been established, These cells co-expressed hepatocyte growth factor (HGF) and its receptor, c-Met, genes in vitro, Reverse-transcriptase/polymerase-chain reaction study revealed that the cells also expressed gene for HGF activator, a recently cloned serine proteinase, suggesting that HGF might have a role in glioma cells in vitro as an autocrine factor, The activator mRNA was also detected in other well-established glioma cell lines, glioma tissues and normal brain, The concomitant expression of HGF, HGF activator and c-met,vas also detected in one glioblastoma case in vivo out of five tested.

引用

页码：78 / 82

页数：5

共 30 条

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