Use of sibling risk ratios and components of genetic variance in the characterization of a simulated oligogenic disease

被引：4

作者：

Almasy, L

Tierney, C

Risch, N

机构：

[1] YALE UNIV, DEPT GENET, NEW HAVEN, CT USA

[2] HARVARD SCH PUBL HLTH, DEPT BIOSTAT, BOSTON, MA USA

[3] YALE UNIV, DEPT EPIDEMIOL & PUBL HLTH, NEW HAVEN, CT 06520 USA

来源：

GENETIC EPIDEMIOLOGY | 1995年 / 12卷 / 06期

关键词：

affected sibling-pairs; TDT; association; components of variance; sibling risk ratio; simulation;

D O I：

10.1002/gepi.1370120607

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Sibling risk ratios are used to quantify the genetic effect of two simulated disease loci, identified through TDT and association methods and characterized via components of variance derived from a relative penetrance matrix. Inconsistencies between the data set and the simulating model are also discussed. (C) 1995 Wiley-Liss, Inc.

引用

页码：565 / 570

页数：6

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