METHOTREXATE-INDUCED CONGENITAL MALFORMATIONS - WITH A REVIEW OF LITERATURE

The case of an infant born after the unsuccessful abortifacient use of methotrexate is reported. The resulting multiple congenital anomalies included absence of the frontal bone, synostosis of the lambdoid and coronal sutures, multiple anomalous ribs, unusual facies, and absence of digits on the left foot with only one digit on the right foot. Mental and motor development was normal, but growth was markedly retarded. The clinical data are compared with 7 other reported cases. The high incidence of cranial anomalies is noted. © 1968 The C. V. Mosby Company.